Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin
نویسندگان
چکیده
منابع مشابه
Malarial Pigment Hemozoin and the Innate Inflammatory Response
Malaria is a deadly infectious disease caused by the intraerythrocytic protozoan parasite Plasmodium. The four species of Plasmodium known to affect humans all produce an inorganic crystal called hemozoin (HZ) during the heme detoxification process. HZ is released from the food vacuole into circulation during erythrocyte lysis, while the released parasites further infect additional naive red bl...
متن کاملToll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
Malaria parasites within red blood cells digest host hemoglobin into a hydrophobic heme polymer, known as hemozoin (HZ), which is subsequently released into the blood stream and then captured by and concentrated in the reticulo-endothelial system. Accumulating evidence suggests that HZ is immunologically active, but the molecular mechanism(s) through which HZ modulates the innate immune system ...
متن کاملHemozoin (Malarial Pigment) Directly Promotes Apoptosis of Erythroid Precursors
Severe malarial anemia is the most common syndrome of severe malaria in endemic areas. The pathophysiology of chronic malaria is characterised by a striking degree of abnormal development of erythroid precursors (dyserythropoiesis) and an inadequate erythropoietic response in spite of elevated levels of erythropoietin. The cause of dyserythropoiesis is unclear although it has been suggested tha...
متن کاملHemozoin Pigment: An Important Tool for Low Parasitemic Malarial Diagnosis
Low parasitemic condition in malaria remains a diagnostic challenge; as the available diagnostic methods failed to detect. Currently, hemozoin (Hz) pigment is gaining attention in the diagnosis of malaria. The major drawback is ease of detection of Hz in routine practice. A pilot study was conducted to evaluate the role of Hz pigment and to compare the performance of quantitative buffy coat ass...
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ژورنال
عنوان ژورنال: Microbes and Infection
سال: 2015
ISSN: 1286-4579
DOI: 10.1016/j.micinf.2014.11.001